Impact of ozone exposure on the phagocytic activity of human surfactant protein A (SP-A) and SP-A variants

Surfactant protein A (SP-A) enhances phagocytosis of Pseudomonas aeruginosa. SP-A1 and SP-A2 encode human (h) SP-A; SP-A2 products enhance phagocytosis more than SP-A1. Oxidation can affect SP-A function. We hypothesized that in vivo and in vitro ozone-induced oxidation of SP-A (as assessed by its c...

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Autors principals: Mikerov, Anatoly N., Umstead, Todd M., Gan, Xiaozhuang, Huang, Weixiong, Guo, Xiaoxuan, Wang, Guirong, Phelps, David S., Floros, Joanna
Format: Artigo
Idioma:Inglês
Publicat: 2007
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964667/
https://ncbi.nlm.nih.gov/pubmed/17981957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00288.2007
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