Macrophage-dependent nitric oxide expression regulates tumor cell detachment and metastasis after IL-2/anti-CD40 immunotherapy

Using an orthotopic model of renal cell carcinoma, we showed previously that IL-2/anti-CD40 immunotherapy resulted in synergistic anti-tumor responses, whereas IL-2 or α-CD40 alone mediated partial transient anti-tumor effects. We now show that treatment of tumor-bearing mice with IL-2/α-CD40, but n...

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Main Authors: Weiss, Jonathan M., Ridnour, Lisa A., Back, Tim, Hussain, S. Perwez, He, Peijun, Maciag, Anna E., Keefer, Larry K., Murphy, William J., Harris, Curtis C., Wink, David A., Wiltrout, Robert H.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964582/
https://ncbi.nlm.nih.gov/pubmed/20921282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20100670
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