Caspase-10-Dependent Cell Death in Fas/CD95 Signalling Is Not Abrogated by Caspase Inhibitor zVAD-fmk

BACKGROUND: Upon CD95/Fas ligation, the initiator caspase-8 is known to activate effector caspases leading to apoptosis. In the presence of zVAD-fmk, a broad-spectrum caspase inhibitor, Fas engagement can also trigger an alternative, non-apoptotic caspase-independent form of cell death, which is ini...

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Bibliographic Details
Main Authors: Lafont, Elodie, Milhas, Delphine, Teissié, Justin, Therville, Nicole, Andrieu-Abadie, Nathalie, Levade, Thierry, Benoist, Hervé, Ségui, Bruno
Format: Artigo
Language:Inglês
Published: Public Library of Science 2010
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964310/
https://ncbi.nlm.nih.gov/pubmed/21049020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0013638
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