Sildenafil increases chemotherapeutic efficacy of doxorubicin in prostate cancer and ameliorates cardiac dysfunction

We have shown that the potent phosphodiesterase-5 (PDE-5) inhibitor sildenafil (Viagra) induces a powerful effect on reduction of infarct size following ischemia/reperfusion injury and improvement of left ventricular dysfunction in the failing heart after myocardial infarction or doxorubicin (DOX) t...

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Hlavní autoři: Das, Anindita, Durrant, David, Mitchell, Clint, Mayton, Eric, Hoke, Nicholas N., Salloum, Fadi N., Park, Margaret A., Qureshi, Ian, Lee, Ray, Dent, Paul, Kukreja, Rakesh C.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2010
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964209/
https://ncbi.nlm.nih.gov/pubmed/20884855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1006965107
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