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Syndecan-1 couples the insulin-like growth factor-1 receptor to inside-out integrin activation
Syndecan-1 (Sdc1) engages and activates the αvβ3 (and/or αvβ5) integrin when clustered in human carcinoma and endothelial cells. Although the engagement is extracellular, the activation mechanism is cytoplasmic. This talin-dependent, inside-out signaling pathway is activated downstream of the insuli...
Uloženo v:
| Hlavní autoři: | , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Company of Biologists
2010
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2964108/ https://ncbi.nlm.nih.gov/pubmed/20971705 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.067645 |
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