Association Between the pfmdr1 Gene and In Vitro Artemether and Lumefantrine Sensitivity in Thai Isolates of Plasmodium falciparum

We evaluated the influence of pfmdr1 mutations and copy number on in vitro artemether and lumefantrine sensitivity in 101 laboratory and adapted Thai isolates of Plasmodium falciparum. Approximately one-fourth of these isolates exhibited reduced lumefantrine susceptibility. We found that both mutati...

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Bibliografiske detaljer
Main Authors: Mungthin, Mathirut, Khositnithikul, Rommanee, Sitthichot, Naruemon, Suwandittakul, Nantana, Wattanaveeradej, Veerachai, Ward, Stephen A., Na-Bangchang, Kesara
Format: Artigo
Sprog:Inglês
Udgivet: The American Society of Tropical Medicine and Hygiene 2010
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2963959/
https://ncbi.nlm.nih.gov/pubmed/21036827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4269/ajtmh.2010.10-0339
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