Association Between the pfmdr1 Gene and In Vitro Artemether and Lumefantrine Sensitivity in Thai Isolates of Plasmodium falciparum

We evaluated the influence of pfmdr1 mutations and copy number on in vitro artemether and lumefantrine sensitivity in 101 laboratory and adapted Thai isolates of Plasmodium falciparum. Approximately one-fourth of these isolates exhibited reduced lumefantrine susceptibility. We found that both mutati...

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Detalhes bibliográficos
Main Authors: Mungthin, Mathirut, Khositnithikul, Rommanee, Sitthichot, Naruemon, Suwandittakul, Nantana, Wattanaveeradej, Veerachai, Ward, Stephen A., Na-Bangchang, Kesara
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society of Tropical Medicine and Hygiene 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2963959/
https://ncbi.nlm.nih.gov/pubmed/21036827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4269/ajtmh.2010.10-0339
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