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Measuring Topology of Low-Intensity DNA Methylation Sites for High Throughput Assessment of Epigenetic Drug-Induced Effects in Cancer Cells
Epigenetic anti-cancer drugs with demethylating effects have shown to alter genome organization in mammalian cell nuclei. The interest in the development of novel epigenetic drugs has increased the demand for cell-based assays to evaluate drug performance in pre-clinical studies. An imaging-based cy...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2963693/ https://ncbi.nlm.nih.gov/pubmed/20813111 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2010.08.013 |
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