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Automated Quantification of DNA Demethylation Effects in Cells via 3D Mapping of Nuclear Signatures and Population Homogeneity Assessment

BACKGROUND: Today’s advanced microscopic imaging applies to the preclinical stages of drug discovery that employ high-throughput and high-content three-dimensional (3D) analysis of cells to more efficiently screen candidate compounds. Drug efficacy can be assessed by measuring response homogeneity t...

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Detalhes bibliográficos
Main Authors: Gertych, Arkadiusz, Wawrowsky, Kolja A., Lindsley, Erik, Vishnevsky, Eugene, Farkas, Daniel L., Tajbakhsh, Jian
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2763559/
https://ncbi.nlm.nih.gov/pubmed/19459215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cyto.a.20740
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