Pharmacological Vasodilation Improves Insulin-Stimulated Muscle Protein Anabolism but Not Glucose Utilization in Older Adults

OBJECTIVE: Skeletal muscle protein metabolism is resistant to the anabolic action of insulin in healthy, nondiabetic older adults. This defect is associated with impaired insulin-induced vasodilation and mTORC1 signaling. We hypothesized that, in older subjects, pharmacological restoration of insuli...

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Main Authors: Timmerman, Kyle L., Lee, Jessica L., Fujita, Satoshi, Dhanani, Shaheen, Dreyer, Hans C., Fry, Christopher S., Drummond, Micah J., Sheffield-Moore, Melinda, Rasmussen, Blake B., Volpi, Elena
Formato: Artigo
Idioma:Inglês
Publicado: American Diabetes Association 2010
Assuntos:
Metabolism
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2963534/
https://ncbi.nlm.nih.gov/pubmed/20724580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-0415
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