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Interdependent Phosphorylation within the Kinase Domain T-loop Regulates CHK2 Activity
Chk2 is a critical regulator of the cellular DNA damage repair response. Activation of Chk2 in response to IR-induced damage is initiated by phosphorylation of the Chk2 SQ/TQ cluster domain at Ser(19), Ser(33), Ser(35), and Thr(68). This precedes autophosphorylation of Thr(383)/Thr(387) in the T-loo...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2963420/ https://ncbi.nlm.nih.gov/pubmed/20713355 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.149609 |
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