Interdependent Phosphorylation within the Kinase Domain T-loop Regulates CHK2 Activity

Chk2 is a critical regulator of the cellular DNA damage repair response. Activation of Chk2 in response to IR-induced damage is initiated by phosphorylation of the Chk2 SQ/TQ cluster domain at Ser(19), Ser(33), Ser(35), and Thr(68). This precedes autophosphorylation of Thr(383)/Thr(387) in the T-loo...

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Bibliographic Details
Main Authors: Guo, Xin, Ward, Michael D., Tiedebohl, Jessica B., Oden, Yvonne M., Nyalwidhe, Julius O., Semmes, O. John
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2963420/
https://ncbi.nlm.nih.gov/pubmed/20713355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.149609
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