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Intravenous administration of phosphorylated acid alpha-glucosidase leads to uptake of enzyme in heart and skeletal muscle of mice.

The lysosomal storage disorder glycogenosis type II is caused by acid alpha-glucosidase deficiency. In this study we have investigated the possible applicability of mannose 6-phosphate receptor-mediated enzyme replacement therapy to correct the enzyme deficiency in the most affected tissues. Bovine...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Van der Ploeg, A T, Kroos, M A, Willemsen, R, Brons, N H, Reuser, A J
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 1991
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC296338/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1991835/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI115025
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