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A New Role for PTEN in Regulating Transient Receptor Potential Canonical Channel 6-mediated Ca(2+) Entry, Endothelial Permeability, and Angiogenesis
Phosphatase and tensin homologue (PTEN) is a dual lipid-protein phosphatase that catalyzes the conversion of phosphoinositol 3,4,5-triphosphate to phosphoinositol 4,5-bisphosphate and thereby inhibits PI3K-Akt-dependent cell proliferation, migration, and tumor vascularization. We have uncovered a pr...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2963370/ https://ncbi.nlm.nih.gov/pubmed/20705603 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.142034 |
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