Inhibition of endothelial cell Ca(2+) entry and transient receptor potential channels by Sigma-1 receptor ligands

BACKGROUND AND PURPOSE: The Sigma-1 receptor (Sig1R) impacts on calcium ion signalling and has a plethora of ligands. This study investigated Sig1R and its ligands in relation to endogenous calcium events of endothelial cells and transient receptor potential (TRP) channels. EXPERIMENTAL APPROACH: In...

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Detalhes bibliográficos
Main Authors: Amer, Mohamed S, McKeown, Lynn, Tumova, Sarka, Liu, Ruifeng, Seymour, Victoria AL, Wilson, Lesley A, Naylor, Jacqueline, Greenhalgh, Katriona, Hou, Bing, Majeed, Yasser, Turner, Paul, Sedo, Alicia, O'Regan, David J, Li, Jing, Bon, Robin S, Porter, Karen E, Beech, David J
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2013
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3596649/
https://ncbi.nlm.nih.gov/pubmed/23121507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12041
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