Insights into an Unusual Nonribosomal Peptide Synthetase Biosynthesis: IDENTIFICATION AND CHARACTERIZATION OF THE GE81112 BIOSYNTHETIC GENE CLUSTER

The GE81112 tetrapeptides (1–3) represent a structurally unique class of antibiotics, acting as specific inhibitors of prokaryotic protein synthesis. Here we report the cloning and sequencing of the GE81112 biosynthetic gene cluster from Streptomyces sp. L-49973 and the development of a genetic mani...

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Hlavní autoři: Binz, Tina M., Maffioli, Sonia I., Sosio, Margherita, Donadio, Stefano, Müller, Rolf
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
Genomics and Proteomics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2963348/
https://ncbi.nlm.nih.gov/pubmed/20710026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.146803
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