SEF/IL-17R (SEFIR) Is Not Enough: AN EXTENDED SEFIR DOMAIN IS REQUIRED FOR IL-17RA-MEDIATED SIGNAL TRANSDUCTION

IL-17, the hallmark cytokine of the Th17 population, mediates immunity to extracellular pathogens and promotes autoimmune immunopathology. The signaling mechanisms triggered by the IL-17 receptor (IL-17RA) and related receptors are strikingly different from other cytokine subclasses. Namely, IL-17Rs...

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Bibliographic Details
Main Authors: Onishi, Reiko M., Park, Sangmi J., Hanel, Walter, Ho, Allen W., Maitra, Amarnath, Gaffen, Sarah L.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2963341/
https://ncbi.nlm.nih.gov/pubmed/20729198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.121418
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