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The role of VHL in clear-cell renal cell carcinoma and its relation to targeted therapy
The basic biology underlying the development of clear-cell renal cell carcinoma (ccRCC) is critically dependent on the von Hippel–Lindau gene (VHL), whose protein product is important in the cell’s normal response to hypoxia. Aberrations in VHL’s function, either through mutation or promoter hyperme...
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| Hlavní autor: | |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2009
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2963106/ https://ncbi.nlm.nih.gov/pubmed/19657325 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ki.2009.296 |
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