Rituximab treatment in patients with active Graves' orbitopathy: effects on proinflammatory and humoral immune reactions

In active Graves' orbitopathy (GO), proinflammatory cytokines predominate. Circulating thyroid stimulating hormone (TSH)-receptor antibodies (TRAb) have been correlated with GO clinical activity and severity. In preliminary studies rituximab (RTX), an anti-CD 20 monoclonal antibody, has induced...

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Detalhes bibliográficos
Main Authors: Vannucchi, G, Campi, I, Bonomi, M, Covelli, D, Dazzi, D, Currò, N, Simonetta, S, Bonara, P, Persani, L, Guastella, C, Wall, J, Beck-Peccoz, P, Salvi, M
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2010
Assuntos:
Translational Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2962960/
https://ncbi.nlm.nih.gov/pubmed/20529087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2249.2010.04191.x
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