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Inhibition of p53 Transcriptional Activity: A Potential Target for Future Development of Therapeutic Strategies for Primary Demyelination

Oligodendrogliopathy, microglial infiltration, and lack of remyelination are detected in the brains of patients with multiple sclerosis and are accompanied by high levels of the transcription factor p53. In this study, we used the cuprizone model of demyelination, characterized by oligodendrogliopat...

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Detalhes bibliográficos
Main Authors: Li, Jiadong, Ghiani, Cristina A., Kim, Jin Young, Liu, Aixiao, Sandoval, Juan, DeVellis, Jean, Casaccia-Bonnefil, Patrizia
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2962898/
https://ncbi.nlm.nih.gov/pubmed/18550754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0184-08.2008
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