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Characterization of 5-Chloro-5-Deoxy-d-Ribose 1-Dehydrogenase in Chloroethylmalonyl Coenzyme A Biosynthesis: SUBSTRATE AND REACTION PROFILING

SalM is a short-chain dehydrogenase/reductase enzyme from the marine actinomycete Salinispora tropica that is involved in the biosynthesis of chloroethylmalonyl-CoA, a novel halogenated polyketide synthase extender unit of the proteasome inhibitor salinosporamide A. SalM was heterologously overexpre...

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Bibliografski detalji
Glavni autori: Kale, Andrew J., McGlinchey, Ryan P., Moore, Bradley S.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2010
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2962469/
https://ncbi.nlm.nih.gov/pubmed/20736169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.153833
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