Decreased Expression of ARV1 Results in Cholesterol Retention in the Endoplasmic Reticulum and Abnormal Bile Acid Metabolism

Endoplasmic reticulum (ER) membrane cholesterol is maintained at an optimal concentration of ∼5 mol % by the net impact of sterol synthesis, modification, and export. Arv1p was first identified in the yeast Saccharomyces cerevisiae as a key component of this homeostasis due to its probable role in i...

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Autores principales: Tong, Fumin, Billheimer, Jeffrey, Shechtman, Caryn F., Liu, Ying, Crooke, Roseann, Graham, Mark, Cohen, David E., Sturley, Stephen L., Rader, Daniel J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Lipids
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2962461/
https://ncbi.nlm.nih.gov/pubmed/20663892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.165761
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