Polymorphism in the 3′-untranslated region of TNFα mRNA impairs binding of the post-transcriptional regulatory protein HuR to TNFα mRNA

Tumor necrosis factor α (TNFα) acts as a beneficial mediator in the process of host defence. In recent years major interest has focused on the AU-rich elements (AREs) present in the 3′-untranslated region (3′-UTR) of TNFα mRNA as this region plays a pivotal role in post-transcriptional control of TN...

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Bibliografiska uppgifter
Huvudupphovsmän: Di Marco, Sergio, Hel, Zdenek, Lachance, Claude, Furneaux, Henry, Radzioch, Danuta
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2001
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC29616/
https://ncbi.nlm.nih.gov/pubmed/11160917
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