Sequestration of p53 in the Cytoplasm by Adenovirus Type 12 E1B 55-Kilodalton Oncoprotein Is Required for Inhibition of p53-Mediated Apoptosis

The adenovirus E1B 55-kDa protein is a potent inhibitor of p53-mediated transactivation and apoptosis. The proposed mechanisms include tethering the E1B repression domain to p53-responsive promoters via direct E1B-p53 interaction. Cytoplasmic sequestration of p53 by the 55-kDa protein would impose a...

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Pubblicato in:	J Virol
Autori principali:	Zhao, Lisa Y., Liao, Daiqing
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2003
Soggetti:	Transformation and Oncogenesis
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC296092/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14645574/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.77.24.13171-13181.2003
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