Multispecific Vaccine-Induced Mucosal Cytotoxic T Lymphocytes Reduce Acute-Phase Viral Replication but Fail in Long-Term Control of Simian Immunodeficiency Virus SIVmac239

Given the current difficulties generating vaccine-induced neutralizing antibodies to human immunodeficiency virus (HIV), the focus of the vaccine community has shifted toward creating cytotoxic-T-lymphocyte (CTL)-based vaccines. Recent reports of CTL-based vaccine trials in macaques challenged with...

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Bibliografske podrobnosti
Main Authors: Vogel, Thorsten U., Reynolds, Matthew R., Fuller, Deborah H., Vielhuber, Kathy, Shipley, Tim, Fuller, James T., Kunstman, Kevin J., Sutter, Gerd, Marthas, Marta L., Erfle, Volker, Wolinsky, Steven M., Wang, Chenxi, Allison, David B., Rud, Erling W., Wilson, Nancy, Montefiori, David, Altman, John D., Watkins, David I.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2003
Teme:
Vaccines and Antiviral Agents
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC296068/
https://ncbi.nlm.nih.gov/pubmed/14645590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.24.13348-13360.2003
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