Multispecific Vaccine-Induced Mucosal Cytotoxic T Lymphocytes Reduce Acute-Phase Viral Replication but Fail in Long-Term Control of Simian Immunodeficiency Virus SIVmac239

Given the current difficulties generating vaccine-induced neutralizing antibodies to human immunodeficiency virus (HIV), the focus of the vaccine community has shifted toward creating cytotoxic-T-lymphocyte (CTL)-based vaccines. Recent reports of CTL-based vaccine trials in macaques challenged with...

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Detalles Bibliográficos
Main Authors: Vogel, Thorsten U., Reynolds, Matthew R., Fuller, Deborah H., Vielhuber, Kathy, Shipley, Tim, Fuller, James T., Kunstman, Kevin J., Sutter, Gerd, Marthas, Marta L., Erfle, Volker, Wolinsky, Steven M., Wang, Chenxi, Allison, David B., Rud, Erling W., Wilson, Nancy, Montefiori, David, Altman, John D., Watkins, David I.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2003
Assuntos:
Vaccines and Antiviral Agents
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC296068/
https://ncbi.nlm.nih.gov/pubmed/14645590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.24.13348-13360.2003
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