Chloroquine inhibits the intracellular multiplication of Legionella pneumophila by limiting the availability of iron. A potential new mechanism for the therapeutic effect of chloroquine against intracellular pathogens.

Chloroquine and ammonium chloride, by virtue of their basic properties, have been shown to raise endocytic and lysosomal pH and thereby interfere with normal iron metabolism in a variety of cell types, including mononuclear phagocytes. Cellular iron metabolism is of critical importance to Legionella...

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Опубликовано в: :J Clin Invest
Главные авторы: Byrd, T F, Horwitz, M A
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 1991
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC296041/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2056129/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI115301
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