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Chloroquine inhibits the intracellular multiplication of Legionella pneumophila by limiting the availability of iron. A potential new mechanism for the therapeutic effect of chloroquine against intracellular pathogens.

Chloroquine and ammonium chloride, by virtue of their basic properties, have been shown to raise endocytic and lysosomal pH and thereby interfere with normal iron metabolism in a variety of cell types, including mononuclear phagocytes. Cellular iron metabolism is of critical importance to Legionella...

詳細記述

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書誌詳細
出版年:J Clin Invest
主要な著者: Byrd, T F, Horwitz, M A
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Clinical Investigation 1991
主題:
オンライン・アクセス:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC296041/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2056129/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI115301
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