Treatment with recombinant human tumor necrosis factor-alpha protects rats against the lethality, hypotension, and hypothermia of gram-negative sepsis.

Tumor necrosis factor (TNF) is a peptide secreted by macrophages in response to endotoxin that can produce many of the changes seen in septic shock. After cecal ligation and puncture (CLP) rats gradually develop tachycardia, hypotension, tachypnea, and hypothermia. At 5 h post-CLP, rats have a peak...

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書誌詳細
主要な著者: Alexander, H R, Sheppard, B C, Jensen, J C, Langstein, H N, Buresh, C M, Venzon, D, Walker, E C, Fraker, D L, Stovroff, M C, Norton, J A
フォーマット: Artigo
言語:Inglês
出版事項: 1991
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC295999/
https://ncbi.nlm.nih.gov/pubmed/2056127
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