Treatment with recombinant human tumor necrosis factor-alpha protects rats against the lethality, hypotension, and hypothermia of gram-negative sepsis.

Tumor necrosis factor (TNF) is a peptide secreted by macrophages in response to endotoxin that can produce many of the changes seen in septic shock. After cecal ligation and puncture (CLP) rats gradually develop tachycardia, hypotension, tachypnea, and hypothermia. At 5 h post-CLP, rats have a peak...

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Autori principali: Alexander, H R, Sheppard, B C, Jensen, J C, Langstein, H N, Buresh, C M, Venzon, D, Walker, E C, Fraker, D L, Stovroff, M C, Norton, J A
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1991
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC295999/
https://ncbi.nlm.nih.gov/pubmed/2056127
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