Interleukin-6 enhances hypercalcemia and bone resorption mediated by parathyroid hormone-related protein in vivo.

Tumors frequently induce the multifunctional cytokine IL-6, which has been linked to several paraneoplastic syndromes, most notably cachexia. IL-6 stimulates osteoclast formation, causes mild hypercalcemia, and is produced by bone cells in vitro upon exposure to systemic hormones. Since IL-6 is prod...

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發表在:	J Clin Invest
Principais autores:	de la Mata, J, Uy, H L, Guise, T A, Story, B, Boyce, B F, Mundy, G R, Roodman, G D
格式:	Artigo
語言:	Inglês
出版:	American Society for Clinical Investigation 1995
主題:	Research Article
在線閱讀:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC295971/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7769125/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117990
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