Interleukin-6 enhances hypercalcemia and bone resorption mediated by parathyroid hormone-related protein in vivo.

Tumors frequently induce the multifunctional cytokine IL-6, which has been linked to several paraneoplastic syndromes, most notably cachexia. IL-6 stimulates osteoclast formation, causes mild hypercalcemia, and is produced by bone cells in vitro upon exposure to systemic hormones. Since IL-6 is prod...

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Detalhes bibliográficos
Main Authors: de la Mata, J, Uy, H L, Guise, T A, Story, B, Boyce, B F, Mundy, G R, Roodman, G D
Formato: Artigo
Idioma:Inglês
Publicado em: 1995
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC295971/
https://ncbi.nlm.nih.gov/pubmed/7769125
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