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Transfer of 15-lipoxygenase gene into rabbit iliac arteries results in the appearance of oxidation-specific lipid-protein adducts characteristic of oxidized low density lipoprotein.

Oxidized low density lipoprotein (LDL) possesses several atherogenic properties. The mechanisms by which LDL becomes oxidized in vivo remain unknown, but previous studies have suggested that 15-lipoxygenase may be one of the factors involved in the initiation of LDL oxidation in the arterial wall. 3...

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Dettagli Bibliografici
Pubblicato in:J Clin Invest
Autori principali: Ylä-Herttuala, S, Luoma, J, Viita, H, Hiltunen, T, Sisto, T, Nikkari, T
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 1995
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Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC295952/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7769108/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117971
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