Protease-cleaved iron-transferrin augments oxidant-mediated endothelial cell injury via hydroxyl radical formation.

Previous work has shown that the Pseudomonas-derived protease, pseudomonas elastase (PAE), can modify transferrin to form iron complexes capable of catalyzing the formation of hydroxyl radical (.OH) from neutrophil (PMN)-derived superoxide (.O2-) and hydrogen peroxide (H2O2). As the lung is a major...

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Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Miller, R A, Britigan, B E
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 1995
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC295931/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7769095/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117950
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