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Ets1 blocks terminal differentiation of keratinocytes and induces expression of matrix metalloproteases and innate immune mediators

The transcription factor Ets1 is normally expressed in the proliferative layer of stratified epithelium, but expression of Ets1 is significantly upregulated in squamous cell carcinomas. How elevated levels of Ets1 impact tumor initiation and progression is not well understood. To determine the biolo...

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Autors principals: Nagarajan, Priyadharsini, Chin, Shu Shien, Wang, Dan, Liu, Song, Sinha, Satrajit, Garrett-Sinha, Lee Ann
Format: Artigo
Idioma:Inglês
Publicat: Company of Biologists 2010
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2959112/
https://ncbi.nlm.nih.gov/pubmed/20930145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.062240
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