Increased accumulation of hypoxia-inducible factor-1α with reduced transcriptional activity mediates the antitumor effect of triptolide

BACKGROUND: Hypoxia-inducible factor-1α (HIF-1α), a critical transcription factor to reduced O(2 )availability, has been demonstrated to be extensively involved in tumor survival, aggressive progression, drug resistance and angiogenesis. Thus it has been considered as a potential anticancer target....

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Main Authors: Zhou, Zhao-Li, Luo, Zhi-Guo, Yu, Bing, Jiang, Yi, Chen, Yi, Feng, Jian-Ming, Dai, Mei, Tong, Lin-Jiang, Li, Zheng, Li, Yuan-Chao, Ding, Jian, Miao, Ze-Hong
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2010
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2958983/
https://ncbi.nlm.nih.gov/pubmed/20932347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-9-268
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