Pioglitazone improves lipid and insulin levels in overweight rats on a high cholesterol and fructose diet by decreasing hepatic inflammation

BACKGROUND AND PURPOSE: Nutrient overload leads to obesity and insulin resistance. Pioglitazone, a selective peroxisome proliferator-activated receptor (PPAR)γ agonist, is currently used to manage insulin resistance, but the specific molecular mechanisms activated by PPARγ are not yet fully understo...

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Bibliographic Details
Main Authors: Collino, Massimo, Aragno, Manuela, Castiglia, Sara, Miglio, Gianluca, Tomasinelli, Chiara, Boccuzzi, Giuseppe, Thiemermann, Christoph, Fantozzi, Roberto
Format: Artigo
Language:Inglês
Published: Blackwell Publishing Ltd 2010
Subjects:
Research Papers with Commentaries
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2958635/
https://ncbi.nlm.nih.gov/pubmed/20233219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.00671.x
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