A synthetic tumor necrosis factor-alpha agonist peptide enhances human polymorphonuclear leukocyte-mediated killing of Plasmodium falciparum in vitro and suppresses Plasmodium chabaudi infection in mice.

A peptide corresponding to residues 70-80 of the TNF-alpha polypeptide was synthesized and shown to enhance human PMN-mediated killing of Plasmodium falciparum in vitro and reduced the Plasmodium chabaudi parasitemia in mice. Studies of the mechanism of action showed that the peptide, TNF(70-80), st...

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Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Kumaratilake, L M, Rathjen, D A, Mack, P, Widmer, F, Prasertsiriroj, V, Ferrante, A
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 1995
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC295845/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7738194/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117923
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