Activation of the cardiac Na(+)–Ca(2+) exchanger by sorcin via the interaction of the respective Ca(2+)-binding domains

Sorcin is a penta-EF-hand protein that interacts with intracellular target proteins after Ca(2+) binding. The sarcolemmal Na(+)/Ca(2+) exchanger (NCX1) may be an important sorcin target in cardiac muscle. In this study, RNAi knockdown of sorcin, purified sorcin or sorcin variants was employed in par...

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Detalhes bibliográficos
Main Authors: Zamparelli, Carlotta, Macquaide, Niall, Colotti, Gianni, Verzili, Daniela, Seidler, Tim, Smith, Godfrey L., Chiancone, Emilia
Formato: Artigo
Idioma:Inglês
Publicado em: Academic Press 2010
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2958309/
https://ncbi.nlm.nih.gov/pubmed/20298697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2010.03.003
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