Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects.

To determine whether the impaired insulin-stimulated glucose uptake in obese individuals is associated with altered insulin receptor signaling, we measured both glucose uptake and early steps in the insulin action pathway in intact strips of human skeletal muscle. Biopsies of rectus abdominus muscle...

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Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Goodyear, L J, Giorgino, F, Sherman, L A, Carey, J, Smith, R J, Dohm, G L
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 1995
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC295829/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7537758/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117909
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