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GPCR functional selectivity has therapeutic impact
A plethora of in vitro data have shown that certain ligands may have the property of causing differential activation of signaling pathways mediated via a single receptor (“functional selectivity”). It remains unclear, however, whether functionally selective properties are meaningful in vivo. Data wi...
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| Glavni autor: | |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2007
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2958218/ https://ncbi.nlm.nih.gov/pubmed/17629962 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tips.2007.06.002 |
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