Monocyte transmigration induced by modification of low density lipoprotein in cocultures of human aortic wall cells is due to induction of monocyte chemotactic protein 1 synthesis and is abolished by high density lipoprotein.

Incubation of cocultures of human aortic endothelial (HAEC) and smooth muscle cells (HASMC) with LDL in the presence of 5-10% human serum resulted in a 7.2-fold induction of mRNA for monocyte chemotactic protein 1 (MCP-1), a 2.5-fold increase in the levels of MCP-1 protein in the coculture supernata...

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Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Navab, M, Imes, S S, Hama, S Y, Hough, G P, Ross, L A, Bork, R W, Valente, A J, Berliner, J A, Drinkwater, D C, Laks, H
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 1991
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC295797/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1752961/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI115532
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