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Protection from Doxorubicin-Induced Cardiomyopathy Using the Modified Anthracycline N-Benzyladriamycin-14-valerate (AD 198)

The anthracycline doxorubicin (Dox) is an effective antitumor agent. However, its use is limited because of its toxicity in the heart. N-Benzyladriamycin-14-valerate (AD 198) is a modified anthracycline with antitumor efficacy similar to that of Dox, but with significantly less cardiotoxicity and po...

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Detalhes bibliográficos
Main Authors: Cai, Chun, Lothstein, Leonard, Morrison, R. Ray, Hofmann, Polly A.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2957784/
https://ncbi.nlm.nih.gov/pubmed/20668052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.167965
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