Treatment with Docosahexaenoic Acid, but Not Eicosapentaenoic Acid, Delays Ca(2+)-Induced Mitochondria Permeability Transition in Normal and Hypertrophied Myocardium

Intake of fish oil containing docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) prevents heart failure; however, the mechanisms are unclear. Mitochondrial permeability transition pore (MPTP) opening contributes to myocardial pathology in cardiac hypertrophy and heart failure, and treatment...

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Detalhes bibliográficos
Main Authors: Khairallah, Ramzi J., O'Shea, Karen M., Brown, Bethany H., Khanna, Nishanth, Des Rosiers, Christine, Stanley, William C.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2010
Assuntos:
Cardiovascular
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2957778/
https://ncbi.nlm.nih.gov/pubmed/20624993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.170605
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