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Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia

PTPN2 (protein tyrosine phosphatase non-receptor type 2, also known as TC-PTP) is a cytosolic tyrosine phosphatase that functions as a negative regulator of a variety of tyrosine kinases and other signaling proteins.1–3 In agreement with its role in the regulation of the immune system, PTPN2 was ide...

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Main Authors: Kleppe, Maria, Lahortiga, Idoya, El Chaar, Tiama, De Keersmaecker, Kim, Mentens, Nicole, Graux, Carlos, Van Roosbroeck, Katrien, Ferrando, Adolfo A., Langerak, Anton W., Meijerink, Jules P.P., Sigaux, François, Haferlach, Torsten, Wlodarska, Iwona, Vandenberghe, Peter, Soulier, Jean, Cools, Jan
Format: Artigo
Jezik:Inglês
Izdano: 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2957655/
https://ncbi.nlm.nih.gov/pubmed/20473312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.587
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