Structure-Based Analysis of Toxoplasma gondii Profilin: A Parasite-Specific Motif is Required for Recognition by Toll-like Receptor 11

Profilins promote actin polymerization by exchanging ADP for ATP on monomeric actin, and delivering ATP-actin to growing filament barbed ends. Apicomplexan protozoa like Toxoplasma gondii invade host cells using an actin-dependent gliding motility. Toll-like receptor 11 (TLR11) generates an innate i...

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Hauptverfasser: Kucera, Kaury, Koblansky, A. Alicia, Saunders, Lauren P., Frederick, Kendra B., De La Cruz, Enrique M., Ghosh, Sankar, Modis, Yorgo
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2957522/
https://ncbi.nlm.nih.gov/pubmed/20851125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.09.022
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