Recognition of Profilin by Toll-like Receptor 12 Is Critical for Host Resistance to Toxoplasma gondii

Toll-like receptor 11 (TLR11) recognizes T. gondii profilin (TgPRF) and is required for interleukin-12 production and induction of immune responses that limit cyst burden in Toxoplasma gondii-infected mice. However, TLR11 only modestly affects survival of T. gondii-challenged mice. We report that TL...

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Detalhes bibliográficos
Main Authors: Koblansky, A. Alicia, Jankovic, Dragana, Oh, Hyunju, Hieny, Sara, Sungnak, Waradon, Mathur, Ramkumar, Hayden, Matthew S., Akira, Shizuo, Sher, Alan, Ghosh, Sankar
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3601573/
https://ncbi.nlm.nih.gov/pubmed/23246311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2012.09.016
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