Leptin-induced cardioprotection involves JAK/STAT signaling that may be linked to the mitochondrial permeability transition pore

Leptin-induced protection against myocardial ischemia-reperfusion (I/R) injury involves the activation of the reperfusion injury salvage kinase pathway, incorporating phosphatidylinositol 3-kinase-Akt/protein kinase B and p44/42 MAPK, and the inhibition of the mitochondrial permeability transition p...

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Main Authors: Smith, Christopher C. T., Dixon, Richard A., Wynne, Abigail M., Theodorou, Louise, Ong, Sang-Ging, Subrayan, Sapna, Davidson, Sean M., Hausenloy, Derek J., Yellon, Derek M.
Formato: Artigo
Idioma:Inglês
Publicado: American Physiological Society 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2957356/
https://ncbi.nlm.nih.gov/pubmed/20656889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00092.2010
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