Increased renal phosphodiesterase-5 activity mediates the blunted natriuretic response to a nitric oxide donor in the pregnant rat

Pregnancy is characterized by plasma volume expansion and renal sodium retention with loss of natriuretic response to atrial natriuretic peptide due to increased medullary phosphodiesterase-5 (PDE5). Here, we determined whether natriuretic responses to nitric oxide (NO) are also blunted in pregnancy...

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Main Authors: Sasser, Jennifer M., Ni, Xi-Ping, Humphreys, Michael H., Baylis, Chris
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2010
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2957261/
https://ncbi.nlm.nih.gov/pubmed/20668100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00117.2010
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