Increased renal phosphodiesterase-5 activity mediates the blunted natriuretic response to a nitric oxide donor in the pregnant rat

Pregnancy is characterized by plasma volume expansion and renal sodium retention with loss of natriuretic response to atrial natriuretic peptide due to increased medullary phosphodiesterase-5 (PDE5). Here, we determined whether natriuretic responses to nitric oxide (NO) are also blunted in pregnancy...

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Detaylı Bibliyografya
Asıl Yazarlar: Sasser, Jennifer M., Ni, Xi-Ping, Humphreys, Michael H., Baylis, Chris
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Physiological Society 2010
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Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2957261/
https://ncbi.nlm.nih.gov/pubmed/20668100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00117.2010
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