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Increased renal phosphodiesterase-5 activity mediates the blunted natriuretic response to ANP in the pregnant rat
Normal rat pregnancy is characterized by plasma volume expansion due to renal sodium retention and is associated with a blunted response to natriuretic stimuli, such as atrial natriuretic peptide (ANP). ANP signals via cGMP, and phosphodiesterases (PDE) inactivate cGMP and terminate the natriuretic...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2006
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2765210/ https://ncbi.nlm.nih.gov/pubmed/17003222 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00309.2006 |
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