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Molecular architecture of the DNA replication origin activation checkpoint
Perturbation of DNA replication initiation arrests human cells in G1, pointing towards an origin activation checkpoint. We used RNAi against Cdc7 kinase to inhibit replication initiation and dissect this checkpoint in fibroblasts. We show that the checkpoint response is dependent on three axes coord...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
European Molecular Biology Organization
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2957206/ https://ncbi.nlm.nih.gov/pubmed/20729811 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.201 |
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