Molecular architecture of the DNA replication origin activation checkpoint

Perturbation of DNA replication initiation arrests human cells in G1, pointing towards an origin activation checkpoint. We used RNAi against Cdc7 kinase to inhibit replication initiation and dissect this checkpoint in fibroblasts. We show that the checkpoint response is dependent on three axes coord...

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Bibliografische gegevens
Hoofdauteurs: Tudzarova, Slavica, Trotter, Matthew W B, Wollenschlaeger, Alex, Mulvey, Claire, Godovac-Zimmermann, Jasminka, Williams, Gareth H, Stoeber, Kai
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: European Molecular Biology Organization 2010
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2957206/
https://ncbi.nlm.nih.gov/pubmed/20729811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.201
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